Glyptotherium also occasionally known as the "North American Glyptodon," is an extinct genus of mammals related to the armadillo. The genus is considered an example of north Amerian megafauna, of which most have become extinct. Glyptotherium may have been wiped out by climate change or human interference. The species Glyptotherium texanum went extinct around 12,000 years ago.

Like its living relative, the armadillo, Glyptotherium had a shell which covered its entire body, similar to a turtle. However, unlike a turtle's shell, the Glyptotherium shell was made up of hundreds of small six-sided scales. Some species grew up to six feet long and its armor weighed up to a ton.

Glyptotherium species thrived in tropical and subtropical regions of Florida, South Carolina, and Texas. There is no direct evidence of humans preying on the North American Glyptodon.